Manufacturing Technology for Demethylchlortetracycline(DMCT)

Demethylchlortetracycline(DMCT) is one member of tetracycline family, its antibacterial spectrumis like chlortetracycline. Its action is stronger than tetracycline and chlortetracycline. DMCT is precursor for minocycline and tygecycline.

Demeclocycline Hydrochloride:

(4S,4aS,5aS,6S,12aS)-N-(carbamoyl-7-chloro-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxonaphthacen-4-yl) dimethylammonium chloride Trade names: Bioterciclin, Declomycin, Deganol, Ledermycin, Periciclina, Meciclin u.a. Empirical Formula: C21H21ClN2O8 HCl Molecular Weight: 464.86

Technology Data: Producing Strain: Streptomyces aureofaciens Final titre:9-10g/L Fermentation time:160-170hrs Recovery Yield: 75-80% Product Specification: conform to EP and USP standard