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| Position: Technologies --> Know-How--> Tech Opportunity |
| Manufacturing Polymyxin B Technology |
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Polymyxin B is an antibiotic primarily used for resistant gram negative infections. Polymyxins bind to the cell membrane and alter its structure making it more permeable. The resulting water uptake leads to cell death. They are cationic, basic proteins that act like detergents. Side effects include neurotoxicity and acute renal tubular necrosis. it is commonly used in the topical first aid preparation Neosporin.
Mechanism:
Alters cytoplasmic membrane permeability by binding to a negatively charged site in the lipopolysaccharide layer which has an electrostatic attraction for the positively charged amino groups in the cyclic peptide portion
Fatty acid portion dissolves in hydrophobic region of membrane and disrupts membrane integrity
Leakage of cellular molecules, inhibition of cellular respiration
Binds and inactivates endotoxin
Relative absence of Selective toxicity: nonspecific for cell membranes of any type, highly toxic
Technology data：
Final titre: 2.5±0.2g/lt
Fermentation time: 168 ± 24hrs
Recovery yield: 70% |
| 发表时间：2008-12-24 |
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