Manufacturing Technology for Demethylchlortetracycline(DMCT)
Demethylchlortetracycline(DMCT) is one member of tetracycline family, its antibacterial spectrumis like chlortetracycline. Its action is stronger than tetracycline and chlortetracycline. DMCT is precursor for minocycline and tygecycline.
Demeclocycline Hydrochloride:
(4S,4aS,5aS,6S,12aS)-N-(carbamoyl-7-chloro-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxonaphthacen-4-yl) dimethylammonium chloride
Trade names: Bioterciclin, Declomycin, Deganol, Ledermycin, Periciclina, Meciclin u.a.
Empirical Formula: C21H21ClN2O8 HCl
Molecular Weight: 464.86
Technology Data:
Producing Strain: Streptomyces aureofaciens
Final titre:9-10g/L
Fermentation time:160-170hrs
Recovery Yield: 75-80%
Product Specification: conform to EP and USP standard
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