Indirubin, a compound isolated from a traditional Chinese herbal medicine （Dang Gui Long Hui Wan）, is an effective treatment for chronic myelocytic leukemia. Studies have shown that indirubin or its derivatives act by inhibiting excessive signaling of the cyclin-dependent kinases and Stat3 metabolic pathways. The indirubin compounds are effective in cell culture lines of mammary carcinoma, large cell lung carcinoma, and prostate cancer.
Researchers are now able to synthesize indirubin in pure form, including the derivatives indirubin-5-sulfonate and indirubin-3-monoxime. The mechanisms by which indirubin or its derivatives exert their effects against the cancer process are now quite well known. Current research efforts on understanding cancer are focused strongly on signaling processes, or the means by which molecules communicate and are transformed through well-defined pathways leading to cell growth. Cyclin-dependent kinases.
Now we developed the new process to produce Indirubin by biotransformation and biocatalyst which will replace the process chemical synthesis and plant extraction. The advantage is to reduce the cost and save resources.
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