Ascomycin (FK520)
An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells.
CAS NO.11011-38-4
Purity: >98%
Action: Fully active via yeast rotamase (FK 506 binding protein) inhibition.
Reference: Paul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69. Kawai, M., et al. 1993. FEBS Lett. 316, 107. Pilot-Matias, T.J., et al. 1993. Gene 128, 219. Shafiee, A., et al. 1993. J. Antibiot. 46, 1397. Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467. R: 20/21/22-36/37/38; S: 26-36
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