Hyaluronic acid (HA) is a naturally occurring biopolymer, which serves important biological functions in bacteria and higher animals including humans. Naturally occurring HA may be found in the tissue of higher animals, in particular as intercellular space filler. It is found in greatest concentrations in the vitreous humour of the eye and in the synovial fluid of articular joints.
Since its discovery in human tissue, HA and its derivatives has been largely studied and applied in the biomedical arena. The appeal of this polymer has been accentuated by its high level of biocompatility. It has been used in viscosurgery to allow surgeons to safely create space between tissues. As a microcapsule it can be used for targeted drug delivery. Viscosurgical implants are constructed from HA. Its viscoelastic character has been used to supplement the lubrication in arthritic joints. Finally, because of its high water retention capacity, this EPS (extracellular polysaccharide) also occupies a niche in the lucrative cosmetics market.
The commercial value of HA far exceeds that of other microbial EPS. With an estimated world market value of $US 10000 million, it is sold for up to $US 1000 per kilogram. Compare this with another leading microbial EPS, xanthan gum derived from Xanthomonas campestris, which sells for up to $US 8 per kilogram.
1. Use
for medicine --- eyes and junction surgery (HMW)
for cosmetics----moisturing agent (LMW)
for health care food
2. Market
In 2001,global capacity is 3 billions USD. The demand for HA will go up as new dictions and application are approved and investigated world -wide.Increasing rate is 15% for HA.
3. Patent
Our technology has our IP and don’t infringe other patent
4. Cost of production
RM+EN: 200USD/kg(1000kg/a), if ourproduction capacity is larger, production cost will be lower.
5. Technology
The strain and technological know-how is available. We have developed and
commercilized it for 7 years and have plenty of experience.This technology is
transfered and carried out sucessfully several times.
Final titre: ≥5g/L(based on extract product)
Fermentation time: 20hrs
Strain: Streptococcus zooepidemicus
Status: commercial stage (10M3)
Product specification: food grade, cosmetics grade and pharm grade
中文
