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Position: Technologies --> Technology Categories--> Bio-based Products and enzymes
Production for L-Phenylalanine by fermentation
L-Phenylalanine (abbreviated as L- Phe) with CAS:13734-34-4 is an α-amino acid with the formula HO2CCH(NH2)CH2C6H5, which is found naturally in the breast milk of mammals and in some plants and microorganisms. Manufactured forms are used in food and drink products and are also sold as nutritional supplements for their reputed analgesic and antidepressant effects. L-phenylalanine is a white, powdery solid. L-Phenylalanine (LPA) is an electrically-neutral amino acid, one of the twenty common amino acids used to biochemically form proteins, coded for by DNA.

L-phenylalanine can also be converted into L-tyrosine, another one of the DNA-encoded amino acids. L-tyrosine in turn is converted into L-DOPA, which is further converted into dopamine, norepinephrine, and epinephrine .

Additionally it is one important intermediate for Aspartame ( one kind of Sweeter). Aspartame is an artificial sweetener. It is 180 times as sweet as sugar in typical concentrations, without the high energy value of sugar. While aspartame, like other peptides, has a caloric value of 4 kilocalories (17 kilojoules) per gram, the quantity of aspartame needed to produce a sweet taste is so small that its caloric contribution is negligible, which makes it a popular sweetener for those trying to avoid calories from sugar. The taste of aspartame is not identical to that of sugar: the sweetness of aspartame has a slower onset and longer duration than that of sugar.

Technology:

Final Titre: 35g/L

Fermentation time: 50hrs

Recovery yield: >70%

Conversion rate from glucose: 15%

Strain: E.coli, GMO

Technology Status: Industrial scale

Patent: know-how, no infringement of IP and Patents.
发表时间:2008-7-23
 
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