Demeclocycline (marketed as Declomycin, Declostatin and Ledermycin) is a member of the tetracycline antibiotics group used in various types of bacterial infections. One of its other registered uses is the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) where fluid restriction alone has been ineffective. It is derived from the Streptomyces aureofaciens actinomycete strain. Key intermediate for minocycline and tigercycline.
Chemical name: 2-(amino-hydroxy-methylidene)- 7-chloro-4-dimethylamino- 6,10,11,12a-tetrahydroxy-4, 4a,5,5a,6,12a- hexahydrotetracene-1,3,12-trione
CAS: 127-33-3
Product name: Demeclocycline Hydrochloride(DMCT)
Items Specifications Results
Appearance: Yellow powder Yellow powder
Identification Complies Complies
pH 2.0-3.0 2.7
Specific optical rotation -248°-- -263° -254°
Specific absorbance (385nm) 340-370 356
Related substances
Any impurity No more than 5.0%,only one more than 4.0% Complies
Total impurities No more than 10.0% Complies
Heavy metals Maximum 50 ppm ＜50ppm
Water maximum 3.0% 0.3%
Sulphate ash maximum 0.5% 0.1%
Assay(Anhydrous) 89.5%-102.0% 93.6%
Conclusion: complies with EP5.0
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