Rapamycin(sirolimus)
Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins.
CAS NO. 53123-88-9
Purity: >98%
Action: Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12
Reference: 1. Merck Index., 1996., 12:, 8288., 2. Vezina, C., et al.. 2. Purification and Characterization., J. Antibiot., 1975., 28:, 721., 3. Attur, M.G., R. Patel.,. 3. Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production., Inflamm Res., 2000., 49(1):, 20-26
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