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Position£ºEvents


















































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































Strain and Technology for Transfer
 

ABOUT US:



BTLbio, depending on the science and technology platform of China Academy of Sciences, Tsinghua University , Peking University and so on, devotes to consultation, technology transfer, patent licensing, technology development, technology incubation, engineering, commissioning and training in biological science and biotechnology, and explores actively new models of commercialization of new technology from lab to industry. BTLbio owns R&D group of specialist and professor from famous university and institute, engineering group of experienced engineers from the industry, and marketing group of international partners. BTLbio¡¯s technology is very competitive in the world.



Additionally BTLbio owns the pilot base and guarantee the transferred technology at least is pilot stage, then is given to the industry. BTLbio also owns HPLC, UV, PCR, automatic fermenter and other laboratory equipments. We not only make and supply products, but also provide fermentation related technology to our clients in fine chemical and pharmaceutical industries. From R&D to production, from analytical to QC, we are ready to serve customers' needs. With strong technical and regulatory expertise, we are looking forward to entering long-term partnership with more clients worldwide.



OUR SERVICES:



PRODUCT, TECHNOLOGY and CONSULTING



CONSULTING



• Market Research Report and Feasibility Study Report



• BioTechnology Hunting, Scouting, Consultation and Evaluation



• BioTechnology Brokage, BioTechnology Transfer and Patent Licensing



• Networking of Biotechnology Transfer



TECHNOLOGY TRANSFER



• BioTechnology Integration and BioTechnology Commercialization



• Supplying high¨Cperformance Strain and research materials at Lab Scale or Industrial Scale



• Supplying Fermentation Process, Fine Chemical Synthesis Process, Extraction Process and Purification Process



• Strain Improvement, Process Optimization



ENGINEEING



• Contract Research and Contract Manufacturing



• Scale up of Process from Lab to Industry



• Basic Engineering Design, or Turn-Key Project



• Personnel Training, Erection, Commissioning and Technology Support



 



Technology list of APIs, Additives and Biologics for technology transfer, Welcome to contact with us, we can offer you professional service:


 


TECHNOLOGY, CONSULTING AND PRODUCT TRADING













































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































































ITEMS


TECH DATA


REMARKS


IMMUNOSUPPRESSIVE AGENT


 


 


Ëû¿ËĪ˾


Tacrolimus


 


Final Titre:600-700mg/L


Fermentation time:168hrs


Recovery:40%


FK506


ù·ÓËá


Mycophenoic acid


Final Titre:15g/L


Fermentation time:264hrs


Recovery:70%


Intermediate


for MMF


»·æß¾úËØ A


Cyclosporin A


Final Titre: 10g/L


Fermentation Time:168hrs


Recovery:70%


 


À×ÅÁùËØ(Î÷ÂÞĪ˾)


Rapamycin(Sirolimus)


Final Titre: 600-800g/L


Fermentation Time:216hrs


Recovery:60%


Or intermediate


for Zotarolimus,


Everolimus


and


×ÓÄÒùËØ


Ascomycin


Final Titre: 500g/L


Fermentation Time:216hrs


Recovery:60%


FK520


Or Intermediate


for Pimecrolimus


ANTIBIOTICS


 


 


°¢ÄªÎ÷ÁÖ


AMOXICILLIN


By enzyme process


 


Íò¹ÅùËØ


Vancomycin


Final Titre:9-10g/L


Fermentation Time: 150hrs


Recovery:>70%


 


Ì濼À­Äþ


Teicoplanin


Final Titre:4-5g/L


Fermentation Time: 150hrs


Recovery:>70%


 


´ïÍÐùËØ


Daptomycin


Final Titre2.0g/L


Fermentation Time: 200hrs


Recovery:>40%


Or cubicin


ĪƥÂÞÐÇ


Mupirocin


Final Titre:4-5g/L


Fermentation Time:60-70hrs


Recovery:>75%


 


Pneumocandin B0


Final Titre:1.7g/L


Fermentation Time: 11-12days


Recovery:>60%


Caspofungin


À×ĪÀ­Äþ


Ramoplanin


Final Titre:3g/L


Fermentation Time: 200hrs


Recovery:>60%


 


ÆÕÄÇùËØ£¨Ô­Ê¼Ã¹ËØ£©


Pristinamycin


Final Titre:8/L


Fermentation Time: 150hrs


Recovery:>70%


 


¿ËÀ­Î¬Ëᣨ°ôËᣩ


Clavulanic acid


Final Titre:6g/L


Fermentation Time:105hrs


Recovery:55%


 


Í·æß¾úËØ C


Cephalosporin C


Final Titre:40g/L


Fermentation Time:168hrs


Recovery:80%


¸÷ÖÖÍ·æßÀàÖмäÌå


ÇàùËØG


Penicillin G


Final Titre:120000g/L


Fermentation Time:220hrs


Recovery:80%


 


ºìùËØ


Erythromycin


Final Titre:9-10g/L


Fermentation Time:156hrs


Recovery:60%


ÒÀÍкìùËØ¡¢çúÒÒºìùËØ¡¢µØºìùËØ¡¢ÂÞºìùËØ¡¢°¢ÆæùËغͿËÀ­Ã¹ËصÄÖмäÌå


È¥¼×½ðùËØ


Demethylchlortetracycline (DMCT)


Final Titre:16g/L


Fermentation Time:200hrs


Recovery:75%


Intermediate for


Minocycline,


Tigecylcine


ÁÖ¿ÉùËØ£¨½àùËØ£©


Lincomycin


Final Titre:9-10g/L


Fermentation Time:200hrs


Recovery:80-90%


¿ËÁÖùËØÖмäÌå


Clindamycin


¸Ë¾úëÄ


Bacitracin


Final Titre:1200U/ml


Fermentation Time:50-60hrs


Recovery:95%


Zinc Bacitracin for


Animal feed additive


ÄÇÎ÷ëÄ


Nosiheptide


Final Titre:1700-2000U/ml


Fermentation Time:50hrs


Recovery:95%


Animal feed additive


Á½ÐÔùËØB


Amphotericin B


Final Titre:10000U/ml


Fermentation Time:130-140hrs


Recovery:75%


 


°¢Î¬À­Ã¹ËØ£¨±°Ã¹ËØ£©


Avilamycin


Final Titre:7-8g/L


Fermentation Time:268hrs


Recovery:95%


Animal feed additive


¶÷À­Ã¹ËØ


Enramycin


Final Titre:8-10g/L


Fermentation Time:260hrs


Recovery:95%


Animal feed additive


¿¨ÄÇùËØ


Kanamycin


Final Titre:25g/L


Fermentation Time:240hrs


Recovery:85%


 


¾íÇúùËØ


Capreomycin


Final Titre:11000U/ml


Fermentation Time:150-160hrs


Recovery:75%


 


Çì´óùËØC


Gentamicin C


Final Titre:5-6g/L


Fermentation Time:14days


Recovery:75%


 


Çì´óùËØB


Gentamycin B


Final Titre:1000Mmg/L


Fermentation Time:120-130hrs


Recovery:75%


ÒìÅÁÃ×ÐÇ


£¨Isepamicin£©


¶àÕ³¾úËØB


Polymyxin B


Final titre 2.5 g/l


Fermentation time 72 hrs


Recovery yield 70%


 


Õ³¸Ë¾úËØ E


Polymyxin E


Final titre 600000U/ml


Fermentation time 96 hrs


Recovery yield 75%


 


Ì©ÀÖ¾úËØ


Tylosin


Final titre 15000 U/l


Fermentation time 180 hrs


Recovery yield 70%


 


°ÍÁúùËØ


Paromomycin


Final titre 8g/l


Fermentation time170 hrs


Recovery yield 70%


 


ÖÆù¾úËØ


Nystatin


Final titre 300,000IU/ml


Fermentation time 280 hrs


Recovery yield 85%


 


ÑÎùËØ


Salinomycin


Final titre 80g/l


Fermentation time 268 hrs


Recovery yield 90%


 


½ðùËØ


Chlortetracycline


Final titre 50g/l


Fermentation time 200 hrs


Recovery yield 90%


 


ËÄ»·ËØ


Tetracycline


Final titre 40g/l


Fermentation time 200 hrs


Recovery yield 90%


 


ÍÁùËØ


Oxytetracycline


Final titre 40g/l


Fermentation time 200 hrs


Recovery yield 90%


 


Á´Ã¹ËØ


Streptomycin


Final titre 28,000U/ml


Fermentation time 200 hrs


Recovery yield 80%


 


Àû¸£Ã¹ËØ


Rifamycin


 


Final titre 30g/l


Fermentation time 220 hrs


Recovery yield 75%


 


»ÆùËØ


Flavomycin


Final titre 8g/l


Fermentation time 168 hrs


Recovery yield 90%


 


½Ø¶Ì²à¶úËØ


Pleuromutilin


Final titre 14000U/ml


Fermentation time 300 hrs


Recovery yield 80%


Ì©Ãî¾úËØ


Tiamulin


´ó¹ÛùËØ


Spectinomycin


Final titre 7000-10000U/ml


Fermentation time 130-150 hrs


Recovery yield 70%


 


ĪÄܾúËØ


Monensin


38000u/ml


Final titre 6500-8000U/ml


Fermentation time 140-170 hrs


Recovery yield 70-80%


 


Íײ¼Ã¹ËØ


Tobramycin


Final titre 6500-8000U/ml


Fermentation time 140-170 hrs


Recovery yield 70-80%


 


°²ÆÕùËØ


Apramycin


Final titre 6500-8000U/ml


Fermentation time 140-170 hrs


Recovery yield 70-80%


 


Äá¿ÉùËØ


Nikkomycin


Final titre 7-8 g/l


Fermentation time 70 hrs


Recovery yield 80%


 


Âó½ÇËá


Lysergic acid


Final titre 7-8 g/l


Fermentation time 360 hrs


Recovery yield 70%


For cabergoline and nicergoline


·òÎ÷µØËá


Fusidic Acid


Final titre 4-5 g/l


Fermentation time 200 hrs


Recovery yield 40%


 


ÂóµÏùËØ


Medimycin


 


Final titre 18g/l


Fermentation time 200 hrs


Recovery yield 75%


 


ĪÄܾúËØ


Monensin


Final Titre:40000U/ml


Fermentation Time: 300hrs


Recovery:95%


 


Âí¶ÅùËØ


Maduramicin


Final Titre:612000U/ml


Fermentation Time: 200hrs


Recovery:95%


 


Àû¸£Ã¹ËØ


RIFAMYCIN


Final Titre:25g/L


Fermentation Time:240hrs


Recovery:80%                                        


 


Á×ùËØ


Fosfomycin


 


 


ÂÈùËØ


Chloramphenicol


 


 


»Ò»ÆùËØ


Griseofulvin


 


 


ÂÝÐýùËØ


Spiramycin//Rovamycin


Final Titre:6000U/ml


Fermentation Time: 160hrs


Recovery:75%


 


СŵùËØ


Micronomicin


 


 


ά¼ªÄáÑÇùËØ


Virginmycin


R&D


 


ÁÁ¾ú¼×ËØ£¨¼ÙÃÛ»·¾úËØ£©


Armillarisin a.


 


 


ÃÀ±´Ã¹ËØ


Milbemycin


Seeking


 


ĪÎ÷¾úËØ


Moxidectin


 


 


µÀÀ­¾úËØ


Doramectin


 


 


ÍÁÀ­Ã¹ËØ


Tulathromvcin


Seeking


 


Ã׿¨·Ò¾»


micafungin


R&D


 


°¢Äá·Ò¾»


anidulafungin


R&D


 


 


 


 


Bio-PESTICIDE


 


 


°¢Î¬¾úËØ


Abamectin


 


Final Titre:4.5g/l


Flask:4.8-5.0g/L


Time:240hrs


Recovery:80%


Including


its derivatives


¶àɱ¾úËØ


Spinosad


Final Titre:12g/L


Fermentation Time:200-240hrs


Recovery:80%


Bio-pesticide


¾®¸ÔùËØ


Validamycin


Final Titre: 3-4g/L


Fermentation Time:60-70hrs


Recovery:80%


 


´ºÀ×ùËØ


Kasugamycin


Final Titre: 8000-1000U/ml


Fermentation Time:192hrs


Recovery80%


 


¶à¿¹Ã¹ËØ


Polyoxin


Final Titre: 5000U/ml


Fermentation Time:192hrs


Recovery£º80%


 


ÍÑÂäËá


Abscisic Acid (ABA)


Final Titre:1.6g/L


Fermentation Time:70-72hrs


Recovery:60-65%


Plant hormone


Biopesticide


³àùËØ


Gibberellin (GA3)


Final Titre:2.5-2.8g/L


Fermentation Time:150-160hrs


Recovery:80%


 


ÖÐÉúùËØ


zhongshengmycin


Final Titre:10g/L


Fermentation Time:1200hrs


Recovery:80%


 


¿Ý²ÝÑ¿æ߸˾ú


Bacillus subtilis


Final Titre6000U/ml


Fermentation Time:150-160hrs


Recovery:80%


 


ËÕÔƽð¸Ë¾ú


Bacillus thuringiensis


Final Titre:5500g/ml


Fermentation Time:150-160hrs


Recovery:80%


 


ä¯ÑôùËØ


Liuyangmycin


 


 


ÄþÄÏùËØ


Ningnanmycin


 


 


Á´Ã¹ËØ


streptomycin


 


For agriculture


ANTI-DIABETES


 


 


Ã׸ñÁд¼


Miglitol


Final Titre:2g/L


Fermentation Time:70-72hrs


Recovery:60-65%


Synthesis:90%


 


°¢¿¨²¨ÌÇ


Acarbose


Final Titre:5-6g/L


Fermentation T, ime:130-150hrs


Recovery:30-40%


 


·ü¸ñÁв¨ÌÇ


Veglibose


Chemical synthesis


 


 


 


 


ANTI-TUMOR


 


 


ÈáºìùËØ


Daunomycin


Final Titre:1.5g/L


Fermentation Time:168hrs


Recovery:>67%


For epirubicin,


   Idarubicin,


   doxorubicin


ÑóºìùËØ


Carminomycin


Final titre 0.15 g/l


Fermentation time 168 hrs


Recovery yield 65%


 


Æ«¶ËùËØ


Distamycin


Final titre 2g/l


Fermentation time 120 hrs


Recovery yield 52%


 


²©À³Ã¹ËØ


Bleomycin


Final titre 4g/l


Fermentation time 168 hrs


Recovery yield 70%


 


×Ïɼ´¼


Paclitaxel


Final titre 200mg/l


Fermentation time 120 hrs


Recovery yield 50%


 


Ë¿ÁÑùËØC


Mitomycin C


Final titre 1000mg/l


Fermentation time 200 hrs


Recovery yield 50%


 


°¢Ã¹ËØ


Doxorubicin


Chemical synthesis


Or fermentation


×ØùËØ


Bruneomycin


Final titre 150mg/l


Fermentation time 144 hrs


Recovery yield 60%


 


·ÅÏß¾úËØD


Dactinomycin D


Chemical synthesis


 


±í°¢Ã¹ËØ


Epirubicin


Chemical synthesis


 


ÒÁ´ï±ÈÐÇ


Idarubicin


Chemical synthesis


 


ßÁÈá±ÈÐÇ


Pirarubicin


Chemical synthesis


 


 


 


 


ANTI-CARDIVASCULAR


 


 


Âå·¥ËûÍ¡


Lovastatin


Final Titre:16g/L


Fermentation Time:168hrs


Recovery:70%


 


ÃÀ·¥ËûÍ¡


Compactin


Final Titre:10g/L


Fermentation Time:200-220hrs


 


ÆÕ·¥ËûÍ¡


Pravastatin


Final Titre: 8.0g/l


Conversion rate:70%


Cycle time: 120-144


 


°¢Íз¥ËûÍ¡


Atorvastatin


Chemical synthesis


 


ÈðÊæ·¥ËûÍ¡


Rosuvastatin


Chemical synthesis


 


ÐÁ·¥ËûÍ¡


Simvastatin


Chemical synthesis


 


·ú·¥ËûÍ¡


Fluvastatin


Chemical synthesis


 


 


 


 


ORGANNIC ACID


 


Biobased chemicals


Ò¿µËá


Itaconic Acid


Acid:>6%


Cycle time:40-50hrs


Conversion:>50%


Fermentation data:1.4g/L/hr


The product gets to Pfizer


ÄûÃÊËá


Citric acid


 


 


ç²ÝËá


Shikimic Acid


Titre: 25g/L


 


L-ÈéËá


L-Lactic acid


Acid:16-18%


Conversion rate; 90%


 


±ûͪËá


Pyruvic acid


Titre:55-65g/L


Conversion rate:55-60%


Fermentation time:60hr


Recovery:70%


 


³¤Á´¶þÔªËá


Long-chain dicarbxylic acid


DCA13-18: 180g/L,


Fermentation time:5-6days


 


 


 


 


Bio-based products


 


 


1£¬3-±û¶þ´¼


1,3-propandiol(PDO)


Titre: 85g/L


Conversion rate:60%


Productivity:1.2-1.4g/LH


Chemical


2£¬3-¶¡¶þ´¼


2,3-butandiol


50-65g/L


By product from PDO


¶¡´¼


Butanol


20g/L


 


¸ÊÓÍ


Glycerol


Titre:160g/l


Time:78hrs


Productivity:2g/LH


Mass conversion rate: 48.6%


Chemical


±ûÏ©õ£°·


Acrylamide


Enzyme activity: 1 0g/ml


Acrylonitrile consumption: 0.75t/t


Conversion rate: 99.9%


Chemical


 


ÑÌõ£°·


Nicotinamide


Enzyme activity: 8g/ml


Nicotinonitrile consumption: 0.85t/t


Conversion rate: 99.999%


Assay: 100%


Chemical


ôÇ»ùÒÒËá


Hydroxyacetic acid


Enzyme activity: 0.1g/ml


Glycolonitrile consumption: 0.78t/t


Conversion rate: 99.9%


Assay: 99.5% ( pharma grade)


Chemical


»ÆÔ­½º


Xanthan


Final Titre:5-6g/L


Fermentation Time:36hrs


Recovery:80%


 


çúçêËᣨ¶¡¶þËᣩ


Succinic acid


 


 


Æ»¹ûËá


Malic acid


 


 


Å£»ÇËá


Taurine


 


 


ÒÒËᣨ´×Ëᣩ


Acetic acid


 


 


¾ÛôÇ»ùÖ¬·¾Ëá


Polyhydroxyalkanoates (PHAs)


 


degradable plastics


¾ÛÈéËá


Polylactic acid, PLA


 


 


 


 


 


VITAMIN AND CAROTENOID


 


 


άÉúËØB2


Vitamin B2


Final titre 30g/l


Fermentation time 72 hrs


Recovery yield 80%


 


άÉúËØB12


Vitamin B12


Final titre 250mg/l


TIME:180hrs


 


άÉúËØC


Vitamin C


Final titre 11-12g/l


Fermentation time 60 hrs


Conversion rate; 90%


 


·¬ÇѺìËØ


Lycopene


Final Titre:>1.0g/L


 


ºúÂܲ·ËØ


Beta Carotene


Final Titre:2.5-3.0g/L


Fermentation Time:72hrs


Recovery:75-80%


 


ϺÇàËØ


Astaxanthin


Final Titre:2g/L


 


άÉúËØD2


Vitamin D2


Light reaction


 


άÉúËØD3


Vitamin D3


Light reaction


 


άÉúËØA


Vitamin A


chemical synthesis


 


άÉúËØH


Vitamin H


By fermentation


Or chemical synthesis


Biotin


HORMONE


 


Biotransformation


Hormone


 


 


ÐÛÏ©¶þͪ


Anostenedione(AD)


Final titre 15 g/l


Fermentation time 200 hrs


Recovery yield 75%


Intermediate


 


ÐÛ¶þÏ©¶þͪ


androsta-1,4-diene-3,17-dione


(ADD)


Final titre 10 g/l


Fermentation time 200 hrs


Recovery yield 72%


Intermediate


 


ÆÃÄáËÉÁú


Prednisolone


 


Finaltitre>20g/L(Maximum 70g/L)


time£º5-8 hrs


conversion: 97¡«100£¥


 


غÍèËØ


Testosterone


Final Titre 5g/L


 


È¥Çâ¼×غͪ


Methandrostenolone


Final Titre 10g/L


 


Pregna 1,4,9,17 acetate


Final Titre 5g/L


 


Pregna 1,2,9,21


Final Titre 5g/L


 


ÂÝÄÚõ¥


SPIRONOLACTONE


 


 


ÒÀÆÕÀûͪ


Eplerenone


 


 


ANTISPETIC


 


 


Ò쿹ѪËá


D-isoascorbate


Productivity:18-20g/L


 


ÄÇËûùËØ


Natamycin 


Final Titre:8-10g/L


Fermentation Time:140-150hrs


antiseptic


ÈéËáÁ´Çò¾úËØ


Nisin


 


Natural antiseptic


 


 


 


HEALTHCARE


 


 


¹Èë׸ÊëÄ


Glutathione(GSH)


Titre: 5g/L


Biomass:140g/L


Fermentation time 72 hrs


Recovery yield 45%


 


¸¨Ã¸Q10


Coenzyme Q10


Final titre2.5-3.0 g/l


Fermentation time 96 hrs


Recovery yield 60%


 


͸Ã÷ÖÊËá


Hyaluronic acid (HA)


Final Titre:6-7g/L


Fermentation Time:20hrs


Recovery:90%


Best performance is 10g/L


»¨ÉúËÄÏ©Ëá


Arachidonic acid (AA)


 


Final titre 9+1.5 g/l


Fermentation time 192hrs


Recovery yield: 65%


Food additives


Healthcare


S-ÏÙÜÕ¼×Áò°±Ëá


S-adenosylmethionine (SAMe)


 


 


¶þÊ®¶þ̼ÁùÏ©Ëá


Docosahexaenic Acid(DHA)


 


 


 


 


 


Others


 


 


ÆÕ³À¼


Pullulan


Titre:60-70g/L


Conversion:60-70%


 


ÁéÖ¥¶àÌÇ


Polysaccharide


Final Titre: 1.5g/l


Cordyceps.sinensis


³àÞºÌÇ´¼


Erythritol


 


excipient


Instant Active Yeast


 


Food processing


Yeast extract


 


Food savor


Âó½Ç¹Ì´¼


Ergosterol


 


For Vitamin D


Alpha-cyclodextrin


 


excipient


Beta- cyclodextrin


 


excipient


¼¡ÜÕ


Inosine


Productivity £º100g/L
time£º 90Сʱ
conversion 35%
recovery£º 90%


 


ÄñÜÕ


Guanosine


Titre :50-60g/L.
time:72Сʱ
conversion: 25%
recovery: 90%


 


WEIGHT LOSING


 


 


ÄᲨ˾ËûÍ¡


Lipstatin


Final Titre:8-10g/L


Fermentation Time:168hrs


Recovery:75%


Conversion:77.8%


Orlistat£¨°ÂÀû˾Ëû£©


Weight losing


 


 


 


Enzymes


 


øÖƼÁ


Phytase


20000U/ml


 


Xylase


Inquiry


 


Celluase


Inquiry


 


Amylase


Inquiry


 


Protease


Inquiry


<, /FONT> 


Acylase,


Inquiry


 


Many other,Etc


Inquiry


 


Penicillin G amidase


 


 


 


 


 


Amino acids


Folder & food additives


 


Medicine, Healthcare


É«°±Ëá


L-Tryptophan


Final titer 25-30 g/l


 


±½±û°±Ëá


L-Phenylalanine


Final titer 40 +/- 2 g/l


 


ËÕ°±Ëá


L-Threonine


Final titer 120 g/l


 


¾«°±Ëá


L-Arginine


Final titre > 60 g/l


 


çÓ°±Ëá


L-Valine


Final titre 52 +/- 2 g/l


 


Àµ°±Ëá


L-Lysine


Final titre 160 +/- 10 g/l


 


ÁÁ°±Ëá


L-Leucine£¬


Final Titre:40g/L


Fermentation Time: 65hrs


Recovery:70%


Conversion:20%


 


ÒìÁÁ°±Ëá


L-isoleucine


Final Titre:30g/L


Fermentation Time: 25hrs


Recovery:80%


 


¹È°±õ£°·


L-Glutamine


Final Titre:80g/L


Fermentation Time: 65hrs


Recovery:75%


 


¹È°±Ëá


Glutmate


productivity£º180-200g/L.
time£º36hrs
conversion rate£º70%
recovery £º95%


 
, Times New Roman" size=3>Final Titre6000U/ml

Fermentation Time:150-160hrs


Recovery:80%


 


ËÕÔƽð¸Ë¾ú


Bacillus thuringiensis


Final Titre:5500g/ml


Fermentation Time:150-160hrs


Recovery:80%


 


ä¯ÑôùËØ


Liuyangmycin


 


 


ÄþÄÏùËØ


Ningnanmycin


 


 


Á´Ã¹ËØ


streptomycin


 


For agriculture


ANTI-DIABETES


 


 


Ã׸ñÁд¼


Miglitol


Final Titre:2g/L


Fermentation Time:70-72hrs


Recovery:60-65%


Synthesis:90%


 


°¢¿¨²¨ÌÇ


Acarbose


Final Titre:5-6g/L


Fermentation T, ime:130-150hrs


Recovery:30-40%


 


·ü¸ñÁв¨ÌÇ


Veglibose


Chemical synthesis


 


 


 


 


ANTI-TUMOR


 


 


ÈáºìùËØ


Daunomycin


Final Titre:1.5g/L


Fermentation Time:168hrs


Recovery:>67%


For epirubicin,


   Idarubicin,


   doxorubicin


ÑóºìùËØ


Carminomycin


Final titre 0.15 g/l


Fermentation time 168 hrs


Recovery yield 65%


 


Æ«¶ËùËØ


Distamycin


Final titre 2g/l


Fermentation time 120 hrs


Recovery yield 52%


 


²©À³Ã¹ËØ


Bleomycin


Final titre 4g/l


Fermentation time 168 hrs


Recovery yield 70%


 


×Ïɼ´¼


Paclitaxel


Final titre 200mg/l


Fermentation time 120 hrs


Recovery yield 50%


 


Ë¿ÁÑùËØC


Mitomycin C


Final titre 1000mg/l


Fermentation time 200 hrs


Recovery yield 50%


 


°¢Ã¹ËØ


Doxorubicin


Chemical synthesis


Or fermentation


×ØùËØ


Bruneomycin


Final titre 150mg/l


Fermentation time 144 hrs


Recovery yield 60%


 


·ÅÏß¾úËØD


Dactinomycin D


Chemical synthesis


 


±í°¢Ã¹ËØ


Epirubicin


Chemical synthesis


 


ÒÁ´ï±ÈÐÇ


Idarubicin


Chemical synthesis


 


ßÁÈá±ÈÐÇ


Pirarubicin


Chemical synthesis


 


 


 


 


ANTI-CARDIVASCULAR


 


 


Âå·¥ËûÍ¡


Lovastatin


Final Titre:16g/L


Fermentation Time:168hrs


Recovery:70%


 


ÃÀ·¥ËûÍ¡


Compactin


Final Titre:10g/L


Fermentation Time:200-220hrs


 


ÆÕ·¥ËûÍ¡


Pravastatin


Final Titre: 8.0g/l


Conversion rate:70%


Cycle time: 120-144


 


°¢Íз¥ËûÍ¡


Atorvastatin


Chemical synthesis


 


ÈðÊæ·¥ËûÍ¡


Rosuvastatin


Chemical synthesis


 


ÐÁ·¥ËûÍ¡


Simvastatin


Chemical synthesis


 


·ú·¥ËûÍ¡


Fluvastatin


Chemical synthesis


 


 


 


 


ORGANNIC ACID


 


Biobased chemicals


Ò¿µËá


Itaconic Acid


Acid:>6%


Cycle time:40-50hrs


Conversion:>50%


Fermentation data:1.4g/L/hr


The product gets to Pfizer


ÄûÃÊËá


Citric acid


 


 


ç²ÝËá


Shikimic Acid


Titre: 25g/L


 


L-ÈéËá


L-Lactic acid


Acid:16-18%


Conversion rate; 90%


 


±ûͪËá


Pyruvic acid


Titre:55-65g/L


Conversion rate:55-60%


Fermentation time:60hr


Recovery:70%


 


³¤Á´¶þÔªËá


Long-chain dicarbxylic acid


DCA13-18: 180g/L,


Fermentation time:5-6days


 


 


 


 


Bio-based products


 


 


1£¬3-±û¶þ´¼


1,3-propandiol(PDO)


Titre: 85g/L


Conversion rate:60%


Productivity:1.2-1.4g/LH


Chemical


2£¬3-¶¡¶þ´¼


2,3-butandiol


50-65g/L


By product from PDO


¶¡´¼


Butanol


20g/L


 


¸ÊÓÍ


Glycerol


Titre:160g/l


Time:78hrs


Productivity:2g/LH


Mass conversion rate: 48.6%


Chemical


±ûÏ©õ£°·


Acrylamide


Enzyme activity: 1 0g/ml


Acrylonitrile consumption: 0.75t/t


Conversion rate: 99.9%


Chemical


 


ÑÌõ£°·


Nicotinamide


Enzyme activity: 8g/ml


Nicotinonitrile consumption: 0.85t/t


Conversion rate: 99.999%


Assay: 100%


Chemical


ôÇ»ùÒÒËá


Hydroxyacetic acid


Enzyme activity: 0.1g/ml


Glycolonitrile consumption: 0.78t/t


Conversion rate: 99.9%


Assay: 99.5% ( pharma grade)


Chemical


»ÆÔ­½º


Xanthan


Final Titre:5-6g/L


Fermentation Time:36hrs


Recovery:80%


 


çúçêËᣨ¶¡¶þËᣩ


Succinic acid


 


 


Æ»¹ûËá


Malic acid


 


 


Å£»ÇËá


Taurine


 


 


ÒÒËᣨ´×Ëᣩ


Acetic acid


 


 


¾ÛôÇ»ùÖ¬·¾Ëá


Polyhydroxyalkanoates (PHAs)


 


degradable plastics


¾ÛÈéËá


Polylactic acid, PLA


 


 


 


 


 


VITAMIN AND CAROTENOID


 


 


άÉúËØB2


Vitamin B2


Final titre 30g/l


Fermentation time 72 hrs


Recovery yield 80%


 


άÉúËØB12


Vitamin B12


Final titre 250mg/l


TIME:180hrs


 


άÉúËØC


Vitamin C


Final titre 11-12g/l


Fermentation time 60 hrs


Conversion rate; 90%


 


·¬ÇѺìËØ


Lycopene


Final Titre:>1.0g/L


 


ºúÂܲ·ËØ


Beta Carotene


Final Titre:2.5-3.0g/L


Fermentation Time:72hrs


Recovery:75-80%


 


ϺÇàËØ


Astaxanthin


Final Titre:2g/L


 


άÉúËØD2


Vitamin D2


Light reaction


 


άÉúËØD3


Vitamin D3


Light reaction


 


άÉúËØA


Vitamin A


chemical synthesis


 


άÉúËØH


Vitamin H


By fermentation


Or chemical synthesis


Biotin


HORMONE


 


Biotransformation


Hormone


 


 


ÐÛÏ©¶þͪ


Anostenedione(AD)


Final titre 15 g/l


Fermentation time 200 hrs


Recovery yield 75%


Intermediate


 


ÐÛ¶þÏ©¶þͪ


androsta-1,4-diene-3,17-dione


(ADD)


Final titre 10 g/l


Fermentation time 200 hrs


Recovery yield 72%


Intermediate


 


ÆÃÄáËÉÁú


Prednisolone


 


Finaltitre>20g/L(Maximum 70g/L)


time£º5-8 hrs


conversion: 97¡«100£¥


 


غÍèËØ


Testosterone


Final Titre 5g/L


 


È¥Çâ¼×غͪ


Methandrostenolone


Final Titre 10g/L


 


Pregna 1,4,9,17 acetate


Final Titre 5g/L


 


Pregna 1,2,9,21


Final Titre 5g/L


 


ÂÝÄÚõ¥


SPIRONOLACTONE


 


 


ÒÀÆÕÀûͪ


Eplerenone


 


 


ANTISPETIC


 


 


Ò쿹ѪËá


D-isoascorbate


Productivity:18-20g/L


 


ÄÇËûùËØ


Natamycin 


Final Titre:8-10g/L


Fermentation Time:140-150hrs


antiseptic


ÈéËáÁ´Çò¾úËØ


Nisin


 


Natural antiseptic


 


 


 


HEALTHCARE


 


 


¹Èë׸ÊëÄ


Glutathione(GSH)


Titre: 5g/L


Biomass:140g/L


Fermentation time 72 hrs


Recovery yield 45%


 


¸¨Ã¸Q10


Coenzyme Q10


Final titre2.5-3.0 g/l


Fermentation time 96 hrs


Recovery yield 60%


 


͸Ã÷ÖÊËá


Hyaluronic acid (HA)


Final Titre:6-7g/L


Fermentation Time:20hrs


Recovery:90%


Best performance is 10g/L


»¨ÉúËÄÏ©Ëá


Arachidonic acid (AA)


 


Final titre 9+1.5 g/l


Fermentation time 192hrs


Recovery yield: 65%


Food additives


Healthcare


S-ÏÙÜÕ¼×Áò°±Ëá


S-adenosylmethionine (SAMe)


 


 


¶þÊ®¶þ̼ÁùÏ©Ëá


Docosahexaenic Acid(DHA)


 


 


 


 


 


Others


 


 


ÆÕ³À¼


Pullulan


Titre:60-70g/L


Conversion:60-70%


 


ÁéÖ¥¶àÌÇ


Polysaccharide


Final Titre: 1.5g/l


Cordyceps.sinensis


³àÞºÌÇ´¼


Erythritol


 


excipient


Instant Active Yeast


 


Food processing


Yeast extract


 


Food savor


Âó½Ç¹Ì´¼


Ergosterol


 


For Vitamin D


Alpha-cyclodextrin


 


excipient


Beta- cyclodextrin


 


excipient


¼¡ÜÕ


Inosine


Productivity £º100g/L
time£º 90Сʱ
conversion 35%
recovery£º 90%


 


ÄñÜÕ


Guanosine


Titre :50-60g/L.
time:72Сʱ
conversion: 25%
recovery: 90%


 


WEIGHT LOSING


 


 


ÄᲨ˾ËûÍ¡


Lipstatin


Final Titre:8-10g/L


Fermentation Time:168hrs


Recovery:75%


Conversion:77.8%


Orlistat£¨°ÂÀû˾Ëû£©


Weight losing


 


 


 


Enzymes


 


øÖƼÁ


Phytase


20000U/ml


 


Xylase


Inquiry


 


Celluase


Inquiry


 


Amylase


Inquiry


 


Protease


Inquiry


<, /FONT> 


Acylase,


Inquiry


 


Many other,Etc


Inquiry


 


Penicillin G amidase


 


 


 


 


 


Amino acids


Folder & food additives


 


Medicine, Healthcare


É«°±Ëá


L-Tryptophan


Final titer 25-30 g/l


 


±½±û°±Ëá


L-Phenylalanine


Final titer 40 +/- 2 g/l


 


ËÕ°±Ëá


L-Threonine


Final titer 120 g/l


 


¾«°±Ëá


L-Arginine


Final titre > 60 g/l


 


çÓ°±Ëá


L-Valine


Final titre 52 +/- 2 g/l


 


Àµ°±Ëá


L-Lysine


Final titre 160 +/- 10 g/l


 


ÁÁ°±Ëá


L-Leucine£¬


Final Titre:40g/L


Fermentation Time: 65hrs


Recovery:70%


Conversion:20%


 


ÒìÁÁ°±Ëá


L-isoleucine


Final Titre:30g/L


Fermentation Time: 25hrs


Recovery:80%


 


¹È°±õ£°·


L-Glutamine


Final Titre:80g/L


Fermentation Time: 65hrs


Recovery:75%


 


¹È°±Ëá


Glutmate


productivity£º180-200g/L.
time£º36hrs
conversion rate£º70%
recovery £º95%


 
, Times New Roman" size=3>Final Titre6000U/ml

Fermentation Time:150-160hrs


Recovery:80%


 


ËÕÔƽð¸Ë¾ú


Bacillus thuringiensis


Final Titre:5500g/ml


Fermentation Time:150-160hrs


Recovery:80%


 


ä¯ÑôùËØ


Liuyangmycin


 


 


ÄþÄÏùËØ


Ningnanmycin


 


 


Á´Ã¹ËØ


streptomycin


 


For agriculture


ANTI-DIABETES


 


 


Ã׸ñÁд¼


Miglitol


Final Titre:2g/L


Fermentation Time:70-72hrs


Recovery:60-65%


Synthesis:90%


 


°¢¿¨²¨ÌÇ


Acarbose


Final Titre:5-6g/L


Fermentation T, ime:130-150hrs


Recovery:30-40%


 


·ü¸ñÁв¨ÌÇ


Veglibose


Chemical synthesis


 


 


 


 


ANTI-TUMOR


 


 


ÈáºìùËØ


Daunomycin


Final Titre:1.5g/L


Fermentation Time:168hrs


Recovery:>67%


For epirubicin,


   Idarubicin,


   doxorubicin


ÑóºìùËØ


Carminomycin


Final titre 0.15 g/l


Fermentation time 168 hrs


Recovery yield 65%


 


Æ«¶ËùËØ


Distamycin


Final titre 2g/l


Fermentation time 120 hrs


Recovery yield 52%


 


²©À³Ã¹ËØ


Bleomycin


Final titre 4g/l


Fermentation time 168 hrs


Recovery yield 70%


 


×Ïɼ´¼


Paclitaxel


Final titre 200mg/l


Fermentation time 120 hrs


Recovery yield 50%


 


Ë¿ÁÑùËØC


Mitomycin C


Final titre 1000mg/l


Fermentation time 200 hrs


Recovery yield 50%


 


°¢Ã¹ËØ


Doxorubicin


Chemical synthesis


Or fermentation


×ØùËØ


Bruneomycin


Final titre 150mg/l


Fermentation time 144 hrs


Recovery yield 60%


 


·ÅÏß¾úËØD


Dactinomycin D


Chemical synthesis


 


±í°¢Ã¹ËØ


Epirubicin


Chemical synthesis


 


ÒÁ´ï±ÈÐÇ


Idarubicin


Chemical synthesis


 


ßÁÈá±ÈÐÇ


Pirarubicin


Chemical synthesis


 


 


 


 


ANTI-CARDIVASCULAR


 


 


Âå·¥ËûÍ¡


Lovastatin


Final Titre:16g/L


Fermentation Time:168hrs


Recovery:70%


 


ÃÀ·¥ËûÍ¡


Compactin


Final Titre:10g/L


Fermentation Time:200-220hrs


 


ÆÕ·¥ËûÍ¡


Pravastatin


Final Titre: 8.0g/l


Conversion rate:70%


Cycle time: 120-144


 


°¢Íз¥ËûÍ¡


Atorvastatin


Chemical synthesis


 


ÈðÊæ·¥ËûÍ¡


Rosuvastatin


Chemical synthesis


 


ÐÁ·¥ËûÍ¡


Simvastatin


Chemical synthesis


 


·ú·¥ËûÍ¡


Fluvastatin


Chemical synthesis


 


 


 


 


ORGANNIC ACID


 


Biobased chemicals


Ò¿µËá


Itaconic Acid


Acid:>6%


Cycle time:40-50hrs


Conversion:>50%


Fermentation data:1.4g/L/hr


The product gets to Pfizer


ÄûÃÊËá


Citric acid


 


 


ç²ÝËá


Shikimic Acid


Titre: 25g/L


 


L-ÈéËá


L-Lactic acid


Acid:16-18%


Conversion rate; 90%


 


±ûͪËá


Pyruvic acid


Titre:55-65g/L


Conversion rate:55-60%


Fermentation time:60hr


Recovery:70%


 


³¤Á´¶þÔªËá


Long-chain dicarbxylic acid


DCA13-18: 180g/L,


Fermentation time:5-6days


 


 


 


 


Bio-based products


 


 


1£¬3-±û¶þ´¼


1,3-propandiol(PDO)


Titre: 85g/L


Conversion rate:60%


Productivity:1.2-1.4g/LH


Chemical


2£¬3-¶¡¶þ´¼


2,3-butandiol


50-65g/L


By product from PDO


¶¡´¼


Butanol


20g/L


 


¸ÊÓÍ


Glycerol


Titre:160g/l


Time:78hrs


Productivity:2g/LH


Mass conversion rate: 48.6%


Chemical


±ûÏ©õ£°·


Acrylamide


Enzyme activity: 1 0g/ml


Acrylonitrile consumption: 0.75t/t


Conversion rate: 99.9%


Chemical


 


ÑÌõ£°·


Nicotinamide


Enzyme activity: 8g/ml


Nicotinonitrile consumption: 0.85t/t


Conversion rate: 99.999%


Assay: 100%


Chemical


ôÇ»ùÒÒËá


Hydroxyacetic acid


Enzyme activity: 0.1g/ml


Glycolonitrile consumption: 0.78t/t


Conversion rate: 99.9%


Assay: 99.5% ( pharma grade)


Chemical


»ÆÔ­½º


Xanthan


Final Titre:5-6g/L


Fermentation Time:36hrs


Recovery:80%


 


çúçêËᣨ¶¡¶þËᣩ


Succinic acid


 


 


Æ»¹ûËá


Malic acid


 


 


Å£»ÇËá


Taurine


 


 


ÒÒËᣨ´×Ëᣩ


Acetic acid


 


 


¾ÛôÇ»ùÖ¬·¾Ëá


Polyhydroxyalkanoates (PHAs)


 


degradable plastics


¾ÛÈéËá


Polylactic acid, PLA


 


 


 


 


 


VITAMIN AND CAROTENOID


 


 


άÉúËØB2


Vitamin B2


Final titre 30g/l


Fermentation time 72 hrs


Recovery yield 80%


 


άÉúËØB12


Vitamin B12


Final titre 250mg/l


TIME:180hrs


 


άÉúËØC


Vitamin C


Final titre 11-12g/l


Fermentation time 60 hrs


Conversion rate; 90%


 


·¬ÇѺìËØ


Lycopene


Final Titre:>1.0g/L


 


ºúÂܲ·ËØ


Beta Carotene


Final Titre:2.5-3.0g/L


Fermentation Time:72hrs


Recovery:75-80%


 


ϺÇàËØ


Astaxanthin


Final Titre:2g/L


 


άÉúËØD2


Vitamin D2


Light reaction


 


άÉúËØD3


Vitamin D3


Light reaction


 


άÉúËØA


Vitamin A


chemical synthesis


 


άÉúËØH


Vitamin H


By fermentation


Or chemical synthesis


Biotin


HORMONE


 


Biotransformation


Hormone


 


 


ÐÛÏ©¶þͪ


Anostenedione(AD)


Final titre 15 g/l


Fermentation time 200 hrs


Recovery yield 75%


Intermediate


 


ÐÛ¶þÏ©¶þͪ


androsta-1,4-diene-3,17-dione


(ADD)


Final titre 10 g/l


Fermentation time 200 hrs


Recovery yield 72%


Intermediate


 


ÆÃÄáËÉÁú


Prednisolone


 


Finaltitre>20g/L(Maximum 70g/L)


time£º5-8 hrs


conversion: 97¡«100£¥


 


غÍèËØ


Testosterone


Final Titre 5g/L


 


È¥Çâ¼×غͪ


Methandrostenolone


Final Titre 10g/L


 


Pregna 1,4,9,17 acetate


Final Titre 5g/L


 


Pregna 1,2,9,21


Final Titre 5g/L


 


ÂÝÄÚõ¥


SPIRONOLACTONE


 


 


ÒÀÆÕÀûͪ


Eplerenone


 


 


ANTISPETIC


 


 


Ò쿹ѪËá


D-isoascorbate


Productivity:18-20g/L


 


ÄÇËûùËØ


Natamycin 


Final Titre:8-10g/L


Fermentation Time:140-150hrs


antiseptic


ÈéËáÁ´Çò¾úËØ


Nisin


 


Natural antiseptic


 


 


 


HEALTHCARE


 


 


¹Èë׸ÊëÄ


Glutathione(GSH)


Titre: 5g/L


Biomass:140g/L


Fermentation time 72 hrs


Recovery yield 45%


 


¸¨Ã¸Q10


Coenzyme Q10


Final titre2.5-3.0 g/l


Fermentation time 96 hrs


Recovery yield 60%


 


͸Ã÷ÖÊËá


Hyaluronic acid (HA)


Final Titre:6-7g/L


Fermentation Time:20hrs


Recovery:90%


Best performance is 10g/L


»¨ÉúËÄÏ©Ëá


Arachidonic acid (AA)


 


Final titre 9+1.5 g/l


Fermentation time 192hrs


Recovery yield: 65%


Food additives


Healthcare


S-ÏÙÜÕ¼×Áò°±Ëá


S-adenosylmethionine (SAMe)


 


 


¶þÊ®¶þ̼ÁùÏ©Ëá


Docosahexaenic Acid(DHA)


 


 


 


 


 


Others


 


 


ÆÕ³À¼


Pullulan


Titre:60-70g/L


Conversion:60-70%


 


ÁéÖ¥¶àÌÇ


Polysaccharide


Final Titre: 1.5g/l


Cordyceps.sinensis


³àÞºÌÇ´¼


Erythritol


 


excipient


Instant Active Yeast


 


Food processing


Yeast extract


 


Food savor


Âó½Ç¹Ì´¼


Ergosterol


 


For Vitamin D


Alpha-cyclodextrin


 


excipient


Beta- cyclodextrin


 


excipient


¼¡ÜÕ


Inosine


Productivity £º100g/L
time£º 90Сʱ
conversion 35%
recovery£º 90%


 


ÄñÜÕ


Guanosine


Titre :50-60g/L.
time:72Сʱ
conversion: 25%
recovery: 90%


 


WEIGHT LOSING


 


 


ÄᲨ˾ËûÍ¡


Lipstatin


Final Titre:8-10g/L


Fermentation Time:168hrs


Recovery:75%


Conversion:77.8%


Orlistat£¨°ÂÀû˾Ëû£©


Weight losing


 


 


 


Enzymes


 


øÖƼÁ


Phytase


20000U/ml


 


Xylase


Inquiry


 


Celluase


Inquiry


 


Amylase


Inquiry


 


Protease


Inquiry


<, /FONT> 


Acylase,


Inquiry


 


Many other,Etc


Inquiry


 


Penicillin G amidase


 


 


 


 


 


Amino acids


Folder & food additives


 


Medicine, Healthcare


É«°±Ëá


L-Tryptophan


Final titer 25-30 g/l


 


±½±û°±Ëá


L-Phenylalanine


Final titer 40 +/- 2 g/l


 


ËÕ°±Ëá


L-Threonine


Final titer 120 g/l


 


¾«°±Ëá


L-Arginine


Final titre > 60 g/l


 


çÓ°±Ëá


L-Valine


Final titre 52 +/- 2 g/l


 


Àµ°±Ëá


L-Lysine


Final titre 160 +/- 10 g/l


 


ÁÁ°±Ëá


L-Leucine£¬


Final Titre:40g/L


Fermentation Time: 65hrs


Recovery:70%


Conversion:20%


 


ÒìÁÁ°±Ëá


L-isoleucine


Final Titre:30g/L


Fermentation Time: 25hrs


Recovery:80%


 


¹È°±õ£°·


L-Glutamine


Final Titre:80g/L


Fermentation Time: 65hrs


Recovery:75%


 


¹È°±Ëá


Glutmate


productivity£º180-200g/L.
time£º36hrs
conversion rate£º70%
recovery £º95%


 
Date£º2009-4-29
 
Copyright 2006-2015 by Global Biologicals (G-Bio). All Rights Reserved.
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