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| 【主 题】 ： |
2'-DEOXY-2'-FLUORO-5-IODOCYTIDINE |
| 【联系人名】 ： |
Linna Green |
| 【电子邮件】 ： |
account@bocsci.com |
| 【联系电话】 ： |
15166698109 |
| 【发布日期】 ： |
2016-9-6 |
| 【详细说明】 ： |
2'-DEOXY-2'-FLUORO-5-IODOCYTIDINE, also called
AC1NQP33, SCHEMBL138935, under the IUPAC name 4-
amino-1-[(2R,3R,4R,5R)-3-fluoro-4-hydroxy-5-
(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one;
80791-93-1, is a potent anti-hepatitis C virus (HCV)
agent.Several 2'-deoxy-2'-
halogenoarabinofuranosylcytosines and -uracils
substituted at C-5 of the aglycon with Br or I were
prepd. and evaluated for antiherpetic activity
against both herpes virus type 1 and 2 on monolayers
of Vero cells by the plaque redn. assay. A dose
that reduced the no. of virus plaques by 50% (ED50)
was detd. The 2'-F function showed better antiviral
activity than the corresponding 2'-Br or Cl
congeners.
http://www.bocsci.com/2-deoxy-2-fluoro-5-
iodocytidine-cas-80791-93-1-item-1-242021.html
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English
