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| 【主 题】 ： |
Purmorphamine |
| 【联系人名】 ： |
Linna Green |
| 【电子邮件】 ： |
account@bocsci.com |
| 【联系电话】 ： |
15166698109 |
| 【发布日期】 ： |
2016-9-6 |
| 【详细说明】 ： |
Purmorphamine, under the IUPAC name 9-Cyclohexyl-N-
[4-(4-morpholinyl)phenyl]-2-(1-naphthalenyloxy)-9H-
purin-6-amine, is a cell-permeable 6,9-
trisubstituted purine which directly binds and
activates Smoothened (in HEK293T cell：IC50= ~ 1.5
μM ).So it has been shown to activate the Hedgehog
(Hh) signaling pathway which is important for
regulating embryonic patterning, stem cell renewal,
and tissue regeneration.
In vitro: An activator of the hedgehog (Hh)
signaling pathway by directly binds and activates
Smoothened (in HEK293T cell：IC50= ~ 1.5 μM ).
In vivo: Purmorphamine up-regulates ALP expression
in human mesenchymal stem cell-based constructs on
rats.http://www.bocsci.com/purmorphamine-cas-483367-
10-8-item-84-211514.html
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English
