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| 【主 题】 ： |
Cyt387 |
| 【联系人名】 ： |
Linna Green |
| 【电子邮件】 ： |
account@bocsci.com |
| 【联系电话】 ： |
15166698109 |
| 【发布日期】 ： |
2016-9-6 |
| 【详细说明】 ： |
Cyt387, also called Momelotinib, under the IUPAC
name N-(cyanomethyl)-4-(2-((4-(4-
morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide,
is an ATP competitive inhibitor of JAK1 (IC50 = 11
nM) and JAK2 (IC50 = 18 nM) with potential
antineoplastic activity, which may result result in
the induction of apoptosis and a reduction of tumor
cell proliferation in JAK1/2-expressing tumor cells.
An orally bioavailable small-molecule inhibitor of
Janus kinases 1 and 2 (JAK1/2) with potential
antineoplastic activity (IC50s = 11 and 18 nM,
respectively).http://www.bocsci.com/cyt387-cas-
1056634-68-4-item-84-307720.html
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English
