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| 【主 题】 ： |
Native Malate dehydrogenase from Thermophillic bacteria |
| 【联系人名】 ： |
Lisa Clara |
| 【电子邮件】 ： |
contact@creative-enzymes.com |
| 【联系电话】 ： |
15166698109 |
| 【发布日期】 ： |
2016-8-27 |
| 【详细说明】 ： |
Malate dehydrogenase is an enzyme in the citric acid
cycle that catalyzes the conversion of malate into
oxaloacetate (using NAD+) and vice versa (this is a
reversible reaction). Malate dehydrogenase is not to
be confused with malic enzyme, which catalyzes the
conversion of malate to pyruvate producing NADPH.
Malate dehydrogenase is also involved in
gluconeogenesis, the synthesis of glucose from
smaller molecules. Pyruvate in the mitochondria is
acted upon by pyruvate carboxylase to form
oxaloacetate, a citric acid cycle intermediate. In
order to get the oxaloacetate out of the
mitochondria, malate dehydrogenase reduces it to
malate, and it then traverses the inner
mitochondrial membrane. Once in the cytosol, the
malate is oxidized back to oxaloacetate by cytosolic
malate dehydrogenase. Finally, phosphoenol-pyruvate
carboxy kinase (PEPCK) converts oxaloacetate to
phosphoenol pyruvate.
http://www.creative-enzymes.com/product/Native-
Malate-Dehydrogenase-From-Thermophillic-
Bacteria_3340.html
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English
