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| 【主 题】 ： |
Native Microorganism Malate Dehydrogenase |
| 【联系人名】 ： |
Lisa Clara |
| 【电子邮件】 ： |
contact@creative-enzymes.com |
| 【联系电话】 ： |
5166698109 |
| 【发布日期】 ： |
2016-5-18 |
| 【详细说明】 ： |
Malate dehydrogenase is an enzyme in the citric
acid cycle that catalyzes the conversion of malate
into oxaloacetate (using NAD+) and vice versa
(this is a reversible reaction). Malate
dehydrogenase is not to be confused with malic
enzyme, which catalyzes the conversion of malate
to pyruvate producing NADPH. Malate dehydrogenase
is also involved in gluconeogenesis, the synthesis
of glucose from smaller molecules. Pyruvate in the
mitochondria is acted upon by pyruvate carboxylase
to form oxaloacetate, a citric acid cycle
intermediate. In order to get the oxaloacetate out
of the mitochondria, malate dehydrogenase reduces
it to malate, and it then traverses the inner
mitochondrial membrane. Once in the cytosol, the
malate is oxidized back to oxaloacetate by
cytosolic malate dehydrogenase. Finally,
phosphoenol-pyruvate carboxy kinase (PEPCK)
converts oxaloacetate to phosphoenol
pyruvate.http://www.creative-
enzymes.com/product/Native-Microorganism-Malate-
Dehydrogenase_756.html
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