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| 当前位置： 技术--> 专利技术--> 【专利转让】 |
| 【主 题】 ： |
茴香霉素[Anisomycin] |
| 【联系人名】 ： |
TAD |
| 【电子邮件】 ： |
BTL-INT@QQ.COM |
| 【联系电话】 ： |
13910029404 |
| 【发布日期】 ： |
2009-5-27 |
| 【详细说明】 ： |
茴香霉素[Anisomycin]
Anisomycin, also known as flagecidin is an antibiotic produced by Streptomyces griseolus which inhibits protein synthesis. Partial inhibition of DNA synthesis occurs at anisomycin concentrations that effect 95% inhibition of protein synthesis. Anisomycin can activate stress-activated protein kinases, MAP kinase and other signal transduction pathways.Anisomycin is inactive against bacteria.
Anisomycin interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Anisomycin is also mentioned as a potential psychiatric drug, as it may inhibit the consolidation of new context-specific long-term memories.".
Injection of anisomycin into the hippocampus has been proposed for selective removal of memories.
Anisomycin is used as a component of Martin Lewis Agar, an in- vitro diagnostic product which is used extensively in the United States for the selective isolation of Neisseria gonorrhoeae and Neisseria meningitidis.
Using a novel high-throughput screening assay, Mawji et al showed that anisomycin can sensitize metastatic epithelial cells to anoikis and reduce circulating tumor cell implantation in vivo.
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