|
|
|
| 当前位置： 技术--> 专利技术--> 【专利转让】 |
| 【主 题】 ： |
缬氨霉素[Valinomycin] |
| 【联系人名】 ： |
TAD |
| 【电子邮件】 ： |
BTL-INT@QQ.COM |
| 【联系电话】 ： |
13910029404 |
| 【发布日期】 ： |
2009-5-27 |
| 【详细说明】 ： |
缬氨霉素[Valinomycin]
Valinomycin is a dodecadepsipeptide, that is, it is made of twelve alternating amino acids and esters to form a macrocyclic molecule.
Valinomycin is obtained from the cells of several Streptomyces strains, one of them "S. tsusimaensis" and “S. fulvissimus”.
It is a member of the group of natural neutral ionophores because it doesn't have a residual charge. It consists of enantiomeres D- and L-Valine, D-hydroxyvaleric acid and L-Lactic acid. Structures are alternated bound via amide and ester bridges. Valinomycin is highly selective for potassium ions over sodium ions within the cell membrane. It functions as a potassium-specific transporter and facilitates the movement of potassium ions through lipid membranes "down" an electrochemical potential gradient.The stability constant K for the potassium-valinomycin complex is 106 and for the sodium-valinomycin complex only 10. This difference is important for maintaining the selectivity of valinomycin for the transport of potassium ions (and not sodium ions) in biological systems.
Valinomycin is a potassium selective ionophore. It is used in specific electrodes. Valinomycin is apoptosis inducer. It is used as a tool in membrane research.
|
|
|
|
|
English
