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当前位置: 技术--> 专有技术--> 【技术转让】
【主    题】 : Milbemycin Oxime
【联系人名】 : Linna Green
【电子邮件】 : account@bocsci.com
【联系电话】 : 15166698109
【发布日期】 : 2016-8-26
【详细说明】 : "Prepared by the two natural products, oxidation and oximation, of an 80:20 ratio of milbemycin A3 and A,Milbemycin oxime is a semi-synthetic macrocyclic lactone. As a nematocide and insecticide in veterinary medicine,it opens glutamate sensitive chloride channels in neurons of invertebrates that leads to paralysis by hyperpolarisation of these cells and signal transfer blocking. M1-family aminopeptidase: IC50 = 2.6 μM (Plasmodium falciparum 3D7); Bile acid transporter: IC50 = 3.6 μM (human); TGR5: EC5050 = 36.4 μM (human); HCT-116: IC50 >50 μM (human); GBM: IC50 >50 μM (human)"
 
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