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当前位置: 技术--> 专有技术--> 【技术转让】 |
【主 题】 : |
Milbemycin Oxime |
【联系人名】 : |
Linna Green |
【电子邮件】 : |
account@bocsci.com |
【联系电话】 : |
15166698109 |
【发布日期】 : |
2016-8-26 |
【详细说明】 : |
"Prepared by the two natural products, oxidation and
oximation, of an 80:20 ratio of milbemycin A3 and
A,Milbemycin oxime is a semi-synthetic macrocyclic
lactone. As a nematocide and insecticide in
veterinary medicine,it opens glutamate sensitive
chloride channels in neurons of invertebrates that
leads to paralysis by hyperpolarisation of these
cells and signal transfer blocking.
M1-family aminopeptidase: IC50 = 2.6 μM (Plasmodium
falciparum 3D7); Bile acid transporter: IC50 = 3.6
μM (human); TGR5: EC5050 = 36.4 μM (human); HCT-116:
IC50 >50 μM (human); GBM: IC50 >50 μM (human)"
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