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| 当前位置： 技术--> 专利技术--> 【专利转让】 |
| 【主 题】 ： |
巴佛洛霉素[bafilomycin] |
| 【联系人名】 ： |
TAD |
| 【电子邮件】 ： |
BTL-INT@QQ.COM |
| 【联系电话】 ： |
13910029404 |
| 【发布日期】 ： |
2009-5-27 |
| 【详细说明】 ： |
巴佛洛霉素[bafilomycin]
bafilomycins are a family of toxic macrolide antibiotic derived from Streptomyces griseus. These compounds all appear in the same fermentation and have quite similar biological activity. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase.
The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.
Bafilomycin has antibacterial, antifungal, antineoplastic, immunosuppressive activities. It has been shown to decrease multi-drug resistance.Bafilomycin B1 has been mentioned as a potential antiosteoporotic agent in treating bone lytic diseases.
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English
