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| 他克莫司(Tacrolimus) |
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他克莫司（Tacrolimus,FK506）
CAS No：104987-11-3
Molecular formula: C44H69NO12
Molecular Weight: 882.03
CAS No.: 104987-11-3
USE: immunosuppressant
PURITY: ≥95%
STORAGE: 2-8℃
Tacrolimus is chemically known as a macrolide. It reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP-12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both T-lymphocyte signal transduction and IL-2 transcription. Although this activity is similar to cyclosporin, studies have shown that the incidence of acute rejection is reduced by tacrolimus use over cyclosporin. |
| 发表时间：2008-10-27 |
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English
