普那霉素及其衍生物技术
Pristinamycin is a streptogramin group antibiotic used primarily for the treatment of staphylococcal infections, and to a lesser extent streptococcal infections. It is marketed in Europe by Sanofi-Aventis under the trade name "Pyostacine" which is a mixture of two components, ie, Pristinamycin IA and Pristinamycin IIA (30 : 70) with synergistic antibacterial action.
Pristinamycin IA may contain a minor impurity "Pristinamycin IB" (= "N-Desmethyl Pristinamycin IA").
Pristinamycin IIA may contain a minor impurity "Pristinamycin IIB" (= "Dihydro Pristinamycin IIA").
Pristinamycin IA [CAS 3131-03-1]
Synonyms:
Factor S; Mikamycin B; Mikamycin IA; NSC-92554;Ostreogrycin B; PA-114B1; Pristinamycin P1; Streptogramin B; Vernamycin B-alpha
Pristinamycin IB [CAS 57206-54-9]
Synonyms:
Efepristin; N-Desmethyl Pristinamycin IA; Ostreogrycin B2;Vernamycin B-beta
Quinupristin [CAS 120138-50-3] 喹奴普丁
Quinupristin is a semi-synthetic antibiotic made from Pristinamycin IA
Pristinamycin IIA [CAS 21411-53-0]
Synonyms:
Antibiotic PA-114A; Antibiotic PA-114A1; Factor M; Mikamycin A; NSC-244426; NSC-87432; Ostreogrycin A; PA-114A; RP-12536; Staphylomycin M1; Streptogramin A;
Synergistin A1; Pristinamycin P2; Vernamycin A; Virginiamycin M1
Pristinamycin IIB [CAS 21102-49-8]
Synonyms:
(27R)-26,27-Dihydro Pristinamycin IIA; (27R)-26,27-Dihydro Virginiamycin M1; Ostreogrycin G; Virginiamycin M2; Volpristin
Dalfopristin [CAS 112362-50-2] 达福普丁
Dalfopristin is a semi-synthetic antibiotic made from Pristinamycin IIA ,
Synercid® (quinupristin and dalfopristin powder for injection) I.V., a streptogramin antibacterial agent for intravenous administration, is a sterile lyophilized formulation of two semisynthetic pristinamycin derivatives, quinupristin (derived from pristinamycin IA) and dalfopristin (derived from pristinamycin IIA) in the ratio of 30:70 (w/w).