芬净及其衍生物技术
Technology of Fungins and its derivatives
Micafungin(米卡芬净） is from FR901379 via FR179642. Microbial deacylation was carried out using the cells of Actinoplanes utahensis at first and then those of Streptomyces sp. no. 6907.
Anidulafungin（阿尼芬净） is from Echinocandin B which is a naturally occurring secondary metabolite isolated from fermentation broth of Aspergilus nidulans. Microbial deacylation was carried out from Echinocandin B to echinocandin B nucleus. This cyclic lipopeptide is used as a key intermediate for synthesis of anidulafungin
Caspofungin（卡泊芬净 is from Pneumocandin B0 (also known as Pneumocardin B0 or L-688786) which is a naturally occurring secondary metabolite isolated from fermentation broth of Zalerion arboricola. This cyclic lipopeptide is used as a key intermediate for synthesis of caspofungin [CAS # 162808-62-0] and caspofungin acetate [CAS 179463-17-3], etc.
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