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当前位置: 技术--> 技术分类--> 医药生物技术
西罗莫司及其衍生物技术
雷帕霉素及衍生物技术

Technology of Sirolimus Derivatives

Rapamycin雷帕霉素

Other Names: Sirolimus(西罗莫司); RAPA; RPM; AY-22989; NSC-226080; Rapamune

CAS Registry Number: 53123-88-9

Rapamycin is a macrolide immunosuppressant isolated from Streptomyces hygroscopicus.

Zotarolimus佐他莫司

Other Names: 40-Epi-(N1-tetrazolyl)-rapamycin; ABT-578

CAS Registry Number: 221877-54-9

Molecular Formula: C52H79N5O12

Molecular Weight: 966.2

Zotarolimus is a macrolide immunosuppressant produced by semi-synthesis from rapamycin (sirolimus).

Temsirolimus 替西莫司

Temsirolimus is a macrolide anticancer agent produced by semisynthesis from Rapamycin.

Biolimus  比欧莫司

Biolimus A9 is a macrolide immunosuppressant produced by semi-synthesis from rapamycin (sirolimus).

Everolimus [CAS # 159351-69-6] 依维莫司

Everolimus is a macrolide immunosuppressant produced by semisynthesis from sirolimus.

Pimecrolimus吡美莫司

Synonym: 33-epi-Chloro-33-desoxyascomycin

CAS Registry Number: 137071-32-0

Pimecrolimus is a macrolide immunosuppressant produced by semisynthesis starting from ascomycin.

Ascomycin子囊霉素 (also known as FK520) is a macrolide immunosuppressant produced by fermentation of Streptomyces tsukubaensis or Streptomyces hygroscopicus var. ascomyceticus.

Tacrolimus他克莫司 (also known as FK506) is a secondary metabolite isolated from Streptomyces tsukubaensis. It is a non-polar macrolide with immunosuppressant activity and originally developed by Fujisawa.

Dalbavancin达巴万星

Product Name: A40926-B0

CAS Number: 102961-72-8  Molecular Formula: C83H88CL2N8O29 Molecular Weight: 1732.56

A40926-B0 is a glycopeptide antibiotic structurally similar to teicoplanin and ancomycin. It is used as precursor for synthesis of dalbavancin. It inhibits peptidoglycan synthesis in the cell wall of gram-positive bacteria.

Physico-Chemical Properties:
White or off-white solid; Soluble in water, slightly soluble in methanol, ethanol; insoluble in non-polar organic solvents. HPLC purity: 80% min.

 

 
发表时间:2011-8-9
 
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