酶法生产阿莫西林，氨苄西林，头孢氨苄与头孢羟氨苄工艺技术
Technologies for Carbohydrate Pharmaceuticals
1. 阿莫西林Amoxicillin (CAS 26787-78-0):
Bio-Enzymatic Reaction:
6-APA + D-p-OH-Phenylglycine-Amide (or -Ester) à Amoxicillin
Yield: > 90 % (guaranteed; semi-continuous process with recycling)
> 95 % achieved; semi-continuous process with recycling
Explanation: Semi-continuous bio-enzymatic process with recycling and in situ product recovery. Process and reactor different from Ampicillin-Production
2. 氨苄西林Ampicillin (CAS 69-53-4):
Bio-Enzymatic Reaction:
6-APA + D-Phenylglycine-Amide (or -Ester) à Ampicillin
Yield: > 90% (guaranteed; semi-continuous process with recycling)
> 95% achieved; semi-continuous process with recycling
Explanation: Semi-continuous bio-enzymatic process with recycling and in situ product recovery. Process and reactor different from Amoxicillin-Production
3.头孢氨苄 Cephalexin (CAS 15686-71-2):
Bio-Enzymatic Reaction:
7-ADCA + D-Phenylglycine-Amide (or Ester) à Cephalexin
Yield: >85% (guaranteed; semi-continuous process with recycling)
>90% achieved; semi-continuous process with recycling
4. 头孢羟氨苄Cephadroxil (CAS 50370-12-2) :
Bio-Enzymatic Reaction:
7-ADCA + D-p-OH-Phenylglycine-Amide (or Ester) à Cephadroxil
Yield: > 85% (guaranteed; semi-continuous process with recycling)
90% achieved; semi-continuous process with recycling
5. 侧链与前体Side-Chains ,Precursors:
6-APA (1-year-contract; minimum 250 tons-per-year)
D-p-OH-Phenylglycine base (1-year-contract; minimum 250 tons-per-year)
D-p-OH-Phenylglycine-amide (1-year-contract; minimum 250 tons-per-year)
D-p-OH-Phenylglycine-ester (1-year-contract; minimum 250 tons-per-year)
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