三代胰岛素技术-重组毕赤酵母高效表达
The global insulin market was worth USD 12,476.3 million in 2011 and is expected to reach USD 32,346.7 million in 2018, growing at a CAGR of 12% from 2011 to 2018. In the global market, China is expected to increase its share in the global insulin market to 10.2% by 2018.
Technical Data:
表达菌:毕赤酵母
前体表达量:大于2.0g/L
发酵时间:5天
得率:大于0.7g/L
产品纯度: 大于98% 符合EP标准
工艺流程及各步得率:
发酵 2.26g/L –表达水平
Giga cap 2.25g/L
Transpeptidation 1.17g/L
Quenching 1.14g/L
PLRS 0.97g/L
cristallization 0.96g/L
Deprotection 0.91g/L
Quenching 0.78g/L
PLRPS 0.78g/L
胰岛素API 0.78g/L – 最终得率