雷帕霉素（西罗莫司）类似物：
Rapamycin（sirolimus） is a macrolide immunosuppressant isolated from Streptomyces hygroscopicus.
Physico-Chemical Properties:
Colorless crystalline solid, mp. 183--185 DC; UV max (95% ethanol): 267, 277, 288 nm (E1% 1cm: 417, 541, 416); Optical rotation ([a]D25): -58.2 (methanol); Soluble in ether, chloroform, acetone, methanol and DMF; very sparingly soluble in hexane and petroleum ether; insoluble in water.
Biolimus
Everolimus is a macrolide immunosuppressant produced by semisynthesis from sirolimus.
Physico-Chemical Properties:
Colorless crystalline solid ; UV max (95% ethanol): 267, 277, 288 nm (E1% 1cm: 417, 541, 416); Soluble in ether, chloroform, acetone, methanol and DMF; very sparingly soluble in hexane and petroleum ether; insoluble in water.
Everolimus
Everolimus is a macrolide immunosuppressant produced by semisynthesis from sirolimus.
Physico-Chemical Properties:
Colorless crystalline solid ; UV max (95% ethanol): 267, 277, 288 nm (E1% 1cm: 417, 541, 416); Soluble in ether, chloroform, acetone, methanol and DMF; very sparingly soluble in hexane and petroleum ether; insoluble in water.
Pimecrolimus
Everolimus is a macrolide immunosuppressant produced by semisynthesis from sirolimus.
Physico-Chemical Properties:
Colorless crystalline solid ; UV max (95% ethanol): 267, 277, 288 nm (E1% 1cm: 417, 541, 416); Soluble in ether, chloroform, acetone, methanol and DMF; very sparingly soluble in hexane and petroleum ether; insoluble in water.
Temsirolimus is a macrolide anticancer agent produced by semisynthesis from Rapamycin.
Zotarolimus is a macrolide immunosuppressant produced by semi-synthesis from rapamycin (sirolimus).
Physico-Chemical Properties:
White or off white crystalline solid; Soluble in ether, chloroform, acetone, methanol, DMSO and DMF; insoluble in water.
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